| 产品详情 |
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| Antigenic Specificity | CBFA2T2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunoprecipitation: 2-10 µg/mg lysate, Western Blot: 1:2,000-1:10,000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CBFA2T2 Polyclonal Antibody. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. |
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| Immunogen | n/a |
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| Other Names | DKFZp313F2116, EHT, ZMYND3 CBFA2T2 |
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| Gene, Accession # | Entrez: 9139; Uniprot: O43439 |
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| Catalog # | A303-593A |
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| Price | |
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| Order / More Info | CBFA2T2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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