| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | CBFA2T2 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human, mouse, rat |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 50 µl, 100 µl, 200 µl |
|---|
| Concentration | > 1 mg/ml |
|---|
| Applications | WB, IF/ICC. RUO |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CBFA2T2 Antibody is a Rabbit Polyclonal antibody against CBFA2T2. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. |
|---|
| Immunogen | Recombinant protein of human CBFA2T2. |
|---|
| Other Names | CBFA2T2; EHT; MTGR1; Protein CBFA2T2; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85; core-binding factor; runt domain; alpha subunit 2; translocated to; 2; DKFZp313F2116; ZMYND3 |
|---|
| Gene, Accession # | CBFA2T2, Gene ID: 9139, SwissProt: O43439 |
|---|
| Catalog # | abx005323 |
|---|
| Price | |
|---|
| Order / More Info | CBFA2T2 Antibody from ABBEXA |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|