| 产品详情 |
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| Product Name | Nazartinib |
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| Description | An inhibitor of mutant EGFRs; selective for EGFR mutant cell lines, including H3255 and HCC827 lung adenocarcinoma cells (IC50s = 6.11 and 1.52 nM, respectively) and resistant H1975 NSCLC cells (IC50 = 4.18 nM), over cells expressing wild-type EGFR (IC50 = 160.6 nM for HaCaT keratinocytes); decreases phosphorylation of EGFR in H3255, HCC827, and H1975 cells (EC50s = 5, 1, and 3 nM) and inhibits cell proliferation of H3255, HCC827, and H1975 cells (EC50s = 9, 11, and 25 nM) but does not affect cell proliferation in cell lines containing wild-type EGFR; reduces tumor growth in an HCC827 lung adenocarcinoma mouse xenograft model at doses ranging from 3 to 100 mg/kg per day |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | EGF816 NVS816 EGFR mutation mouse liver blood T790M L858R ex19del r EGF-816 NVS-816 H-3255 1975 HCC-827 |
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| Gene, Accession, CAS # | CAS: 1508250-71-2 |
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| Catalog # | 22409-5 |
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| Price | |
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| Order / More Info | Nazartinib from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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