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| Antigenic Specificity | CD56 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | biotin conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | FCM. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Expression of neural cell adhesion molecules (N-CAM) provides neurons with a means of attaching to and interacting with other cells and the extracellular matrix. Alternative splicing of N-CAM mRNA results in several N-CAM isoforms. The three major isoforms are referred to as 180 kD, 140 kD, and 120 kD. Individual isoforms undergo various post-translational modifications, including the addition of polysialic acid residues to embryonic forms. The highly polysialylated forms of N-CAM present in embryos and neonates are lost during maturation and replaced by less-polysialic acid-laden mature forms of N-CAM. The functional significance of alternative forms of N-CAM remain to be fully elucidated. The CD56 antigen is a 175-185kDa isoform of the neural cell adhesion molecule (NCAM). It is expressed by lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors. It is expressed on natural killer (NK) Cells and a subpopulation of T lymphocytes. NK cells make up approximately 10-25% of peripheral blood lymphocytes. |
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| Immunogen | U937 cell line (Human). |
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| Other Names | CD56; Leu-19; NKH1; NCAM; CAMPATH-1 antige; CDw52; Cambridge pathology 1 antigen; Epididymal secretory protein E5; Human epididymis-specific protein 5; He10; He11; He12; He13; He14; He15; He16; He6; He7; He8; He9; MAb to CD56; Neural cell adhesion molecule 1; N-CAM-1; NCAM-1; CD antigen CD56 |
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| Gene, Accession # | Gene ID: 4684, SwissProt: P31358 |
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| Catalog # | abx200377 |
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| Price | |
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| Order / More Info | CD56 Antibody from ABBEXA |
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| Product Specific References | n/a |
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