| 产品详情 |
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| Antigenic Specificity | ARHGDIA |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, monkey |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IF/ICC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | ARHGDIA Antibody is a Rabbit Polyclonal antibody against ARHGDIA. Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI). RhoGDI affects Rho activity by inhibiting nucleotide exchange and membrane association, regulating activity and localization (Reviewed in 1, 2). The inhibitory and shuttling functions of RhoGDI have been uncoupled using mutant forms of RhoGDI (3). Phosphorylation of GDIs and/or GTPases can modulate their affinity for each other and, therefore, GTPase mediated signaling. PAK1 phosphorylation of RhoGDI at serines 101 and 174 causes release and activation of Rac1, but not RhoA (4). |
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| Immunogen | Recombinant protein of human ARHGDIA. |
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| Other Names | ARHGDIA; GDIA1; MGC117248; RHOGDI; RHOGDI-1; Rho GDP-dissociation inhibitor 1; Rho-GDI alpha; Rho GDP dissociation inhibitor (GDI) alpha; GDIR; Rho GDI 1 |
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| Gene, Accession # | ARHGDIA, Gene ID: 396, SwissProt: P52565 |
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| Catalog # | abx001126 |
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| Price | |
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| Order / More Info | ARHGDIA Antibody from ABBEXA |
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| Product Specific References | n/a |
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