| 产品详情 |
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| Antigenic Specificity | NPM1 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Purified His-tagged NPM1 protein was used to produced this monoclonal antibody. |
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| Immunogen | n/a |
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| Other Names | B23; NPM; NPM1; Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; npm1; nucleophosmin (nucleolar phosphoprotein B23; numatrin); MGC104254 |
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| Gene, Accession # | Accession: NP_001032827.1, NP_002511.1, NP_954654.1, SwissProt: P06748 |
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| Catalog # | abx034838 |
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| Price | |
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| Order / More Info | NPM1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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