| 产品详情 |
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| Antigenic Specificity | DYRK2 |
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| Clone | polyclonal |
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| Host Species | Sheep |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | lyophilized |
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| Applications | Western Blot: 1 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | DYRK2 Polyclonal Antibody. DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase. |
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| Immunogen | n/a |
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| Other Names | dual specificity tyrosine-phosphorylation-regulated kinase 2 |
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| Gene, Accession # | Entrez: 314862, 69181, 8445; Uniprot: Q5U4C9, Q92630 |
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| Catalog # | PA5-47734 |
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| Price | |
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| Order / More Info | DYRK2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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