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| Antigenic Specificity | Phospho-c-Raf (Ser471) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | purified |
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| Size | 400 µL |
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| Concentration | n/a |
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| Applications | Dot blot: 1:500, Immunocytochemistry: 1:100, Immunofluorescence: 1:100 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Phospho-c-Raf (Ser471) Polyclonal Antibody. Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. |
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| Immunogen | n/a |
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| Other Names | RAF proto-oncogene serine/threonine-protein kinase; Raf-1; C-RAF; cRaf; RAF1; RAF; |
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| Gene, Accession # | Entrez: 5894; Uniprot: P04049 |
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| Catalog # | PA5-12767 |
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| Price | |
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| Order / More Info | Phospho-c-Raf (Ser471) Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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