| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | MMP-2 |
|---|
| Clone | M6308B04 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, mouse |
|---|
| Isotype | IgG2b, κ |
|---|
| Format | purified |
|---|
| Size | 100 µg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blot (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Purified anti-MMP2. MMP2, also named gelatinase A and MMP-2, is a member of matrix metalloproteinase family of proteins (MMPs). MMPs are structurally related enzymes that contain zinc that degrade the extracellular matrix and connective tissue proteins in normal physiological processes such as embryonic development, reproduction, and tissue remodeling as well as in disease processes such as arthritis and metastasis. MMP2 consists of a prodomain, which is cleaved upon activation, a catalytic domain containing the zinc binding site, a fibronectin-like domain (that plays a role in the substrate targeting), and a carboxyl-terminal (hemopexin-like repeats) domain. The activation of MMP2 requires proteolytic processing starting first with a complex of membrane type 1 MMP (MT1-MMP) and tissue inhibitor of metalloproteinase 2 recruits pro-MMP2 from the extracellular milieu to the cell surface. The second step of the process is MMP2 activating by active MT1-MMP and subsequent autocatalytic cleavage. Substrates of MMP2 include type IV collagen, aggrecan, link protein, decorin, fibronectin, and type X and XI collagens, which all are components of the articular cartilaginous matrix. Importantly, MMP2 secretion is elevated in several types of human cancers and its elevated expression has been associated with a poor prognosis. Mutations in the MMP2 gene are associated with Torg-Winchester syndrome, multicentric osteolysis, arthritis syndrome, and possibly keloids. MMP2 deficient mice exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland. |
|---|
| Immunogen | Recombinant human MMP-2, amino acids (Ala30-Cys660) (Accession# NP_004521.1) with a C-terminal His tag and a linker sequence. It is expressed in 293E cells. |
|---|
| Other Names | Matrix metallopeptidase 2, Gelatinase A, MMP-2, GelA, Clg4a, CLG4, MONA, TBE-1, MMP-II |
|---|
| Gene, Accession # | Gene ID: 4313 |
|---|
| Catalog # | 680002 |
|---|
| Price | |
|---|
| Order / More Info | MMP-2 Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|