| 产品详情 |
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| Antigenic Specificity | KAL1 |
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| Clone | OTI5E10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:500 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | KAL1 Monoclonal Antibody (OTI5E10). Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex. |
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| Immunogen | n/a |
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| Other Names | ADMLX, HHA, KAL, KALIG-1, KMS; Kallmann syndrome interval gene 1; Kallmann syndrome-1 sequence (anosmin-1); adhesion molecule-like X-linked; anosmin-1; kallmann syndrome protein |
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| Gene, Accession # | Entrez: 3730; Uniprot: P23352 |
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| Catalog # | MA5-27048 |
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| Price | |
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| Order / More Info | KAL1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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