| 产品详情 |
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| Antigenic Specificity | Melanophilin |
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| Clone | OTI6E8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Melanophilin Monoclonal Antibody (OTI6E8). Slac2-a (for synaptotagmin-like protein (Slp) homolog lacking C2 domains-a) links Rab27A on melanosomes with Myosin VA in melanocytes. Slac2-a binds Myosin VA through a C-terminal region and GTP-bound Rab27A through its synaptotagmin-like protein homology domain (SHD), which is located near the N-terminus. The transport of pigment and cytotoxic granules in melanocytes requires the stable formation of this complex, and thus mutations in the binding domains of the three protein components may cause albinism and/or severe immune disorders. |
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| Immunogen | n/a |
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| Other Names | 2210418F23Rik, 5031433I09Rik, AW228792, D1Wsu84e, Slac-2a, l(1)-3Rk, l1Rk3, ln, exophilin-3, leaden protein, slaC2-a, slp homolog lacking C2 domains a, synaptotagmin-like protein 2a |
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| Gene, Accession # | Entrez: 79083; Uniprot: Q9BV36 |
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| Catalog # | MA5-27001 |
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| Price | |
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| Order / More Info | Melanophilin Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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