| 产品详情 |
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| Antigenic Specificity | MDM2 |
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| Clone | MD-219 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 50 µL |
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| Concentration | n/a |
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| Applications | ELISA: Assay Dependent, Flow Cytometry: Assay Dependent, Immunocytochemistry: Assay Dependent, Immunofluorescence: Assay-dependent, Western Blot: 0.5-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MDM2 Monoclonal Antibody (MD-219). MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53. MDM2 is located on chromosome 12 on the q arm. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53. MDM2 has also been shown to negatively regulate p53 function. MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function. Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also |
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| Immunogen | n/a |
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| Other Names | 1700007J15Rik, AA415488, Mdm-2 |
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| Gene, Accession # | Entrez: 17246; Uniprot: P23804 |
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| Catalog # | MA1-24643 |
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| Price | |
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| Order / More Info | MDM2 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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