| 产品详情 |
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| Antigenic Specificity | CCND1 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | ascites |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | ELISA, WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
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| Immunogen | Purified recombinant fragment of human CCND1 expressed in E. Coli. |
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| Other Names | BCL-1 oncogene; BCL1; CCND1; CYL-1; G1/S-specific cyclin D1; PRAD1; PRAD1 oncogene; CCND1 protein; Cyclin D1; isoform CRA_c; cDNA; FLJ93625; Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1); mRNA; PRAD1: parathyroid adenomatosis 1; D11S287E; U21B31; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein |
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| Gene, Accession # | CCND1, Gene ID: 595, SwissProt: P24385 |
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| Catalog # | abx011703 |
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| Price | |
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| Order / More Info | CCND1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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