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| Antigenic Specificity | CCND1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1) /S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-292 amino acids from the C-terminal region of human CCND1. |
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| Immunogen | n/a |
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| Other Names | BCL-1 oncogene; BCL1; CCND1; CYL-1; G1/S-specific cyclin D1; PRAD1; PRAD1 oncogene; CCND1 protein; Cyclin D1; isoform CRA_c; cDNA; FLJ93625; Homo sapiens cyclin D1 (PRAD1: parathyroid adenomatosis 1) (CCND1); mRNA; PRAD1: parathyroid adenomatosis 1; D11S287E; U21B31; G1/S-specific cyclin-D1; B-cell lymphoma 1 protein |
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| Gene, Accession # | Accession: NP_444284.1, SwissProt: P24385 |
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| Catalog # | abx034749 |
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| Price | |
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| Order / More Info | CCND1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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