| 产品详情 |
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| Antigenic Specificity | LCK |
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| Clone | 8E5F9, 4B2C7 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blot: 1/500 - 1/2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LCK Monoclonal Antibody (8E5F9, 4B2C7). LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, |
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| Immunogen | n/a |
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| Other Names | YT16; p56lck; pp58lck; LCK |
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| Gene, Accession # | Entrez: 3932; Uniprot: P06239 |
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| Catalog # | MA5-15295 |
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| Price | |
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| Order / More Info | LCK Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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