| 产品详情 |
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| Product Name | SGC0946 |
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| Description | A potent inhibitor of DOT1L (IC50 = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively) |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | methyltransferase epigenetic histone modification chromatin research inhibit inhibitor DOT1L protein PMTs enzyme methylate 3 three lysine 79 H3K79 catalyze monomethylation dimethylation trimethylation transcriptional gene DNA deoxyribonucleic acid damage repair cell cycle regulation A431 MCF10A bromine brominated analogs S-adenosylmethionine-competitive SAM-competitive EPZ004777 kills mixed lineages leukemia MLL cancers oncogenic fusion SGC 0946 Structural Genomic Consortium |
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| Gene, Accession, CAS # | CAS: 1561178-17-3 |
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| Catalog # | 13967-5 |
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| Price | |
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| Order / More Info | SGC0946 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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