| Edit |   |
|---|
| Antigenic Specificity | NGEF |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | human |
|---|
| Isotype | n/a |
|---|
| Format | purified |
|---|
| Size | 100 µl |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry: 1:50-1:200 |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | NGEF Polyclonal Antibody. Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension. |
|---|
| Immunogen | n/a |
|---|
| Other Names | Ephexin-1, Eph-interacting exchange protein, Neuronal guanine nucleotide exchange factor, NGEF |
|---|
| Gene, Accession # | Entrez: 25791; Uniprot: Q8N5V2 |
|---|
| Catalog # | PA5-52521 |
|---|
| Price | |
|---|
| Order / More Info | NGEF Antibody from INVITROGEN ANTIBODIES |
|---|
| Product Specific References | n/a |
|---|