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| Antigenic Specificity | AKT1 (pT450) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | DB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]. This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T450 of human AKT1. |
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| Immunogen | Human AKT1 (phospho-Thr450). |
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| Other Names | AKT; AKT1 kinase; C-AKT; PKB; PKB-alpha; Protein kinase B; RAC; RAC-PK-alpha; RAC-alpha serine/threonine kinase; kinase Akt1; CWS6; PRKBA; RAC-ALPHA; AKT1; RAC-alpha serine/threonine-protein kinase; Protein kinase B alpha; Proto-oncogene c-Akt; PKB alpha; PK; RAC-PK-beta; Protein kinase; Akt-2; beta RAC-PK-gamma; Protein kinase Akt-3; gamma PKB; gamma STK-2 |
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| Gene, Accession # | SwissProt: P31749 |
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| Catalog # | abx032108 |
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| Price | |
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| Order / More Info | AKT1 (pT450) Antibody from ABBEXA |
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| Product Specific References | n/a |
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