| 产品详情 |
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| Antigenic Specificity | CD41/CD61 |
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| Clone | PAC-1 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgM, κ |
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| Format | fluorescein (FITC) conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FITC anti-human CD41/CD61. The gpIIb/IIIa complex, also known as integrin αIIbβ3, is expressed by megakaryocytes and platelets. It undergoes conformational changes upon activation by substances, such as ADP, thrombin, and TXA2, which subsequently reveals a ligand binding site that is specific for fibrinogen, von Willebrand factor (vWF), fibronectin, and vitronectin. This conformational change is crucial for platelet-platelet adhesion. Ligand bound gpIIb/IIIa complex promotes platelet aggregation. This complex plays an important role in hemostasis and is a target for developing therapeutic antibodies in immune thrombocytopenia. |
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| Immunogen | Human platelets |
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| Other Names | glycoprotein IIb/IIIa complex, gpIIb/IIIa complex, integrin αIIbβ3 |
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| Gene, Accession # | Gene ID: 3674, 3690 |
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| Catalog # | 362803 |
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| Price | |
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| Order / More Info | CD41/CD61 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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