| 产品详情 |
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| Antigenic Specificity | IL-27 |
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| Clone | MM27-7B1 |
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| Host Species | Mouse |
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| Reactive Species | mouse |
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| Isotype | IgG2a |
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| Format | allophycocyanin (APC) conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | APC anti-mouse IL-27 p28. IL-27 is a heterodimeric cytokine consisting of EBV-induced gene-3 (EBI3, an IL-12 p40-related protein) and p28 (a newly discovered IL-12 P35-related protein). It is a member of the IL-6/IL-12 cytokine family and mainly produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 acts on T cells and NK cells. It has been reported that IL-27 drives rapid clonal expansion of naïve CD4+ T cells, and promotes Th1 polarization and IFN-γ production in synergy with IL-12. The IL-27-induced Th1 differentiation was mediated by rapid and marked upregulation of ICAM-1/LFA-1 interaction in a STAT1-dependent manner. IL-27 exhibits anti-inflammatory function by enhancing Th1 cell differentiation, a potent antitumor activity, through CD8+ T cell and NK cell activation. It also plays a potential therapeutic role in autoimmune disease by inhibiting Th-17 development. IL-27 mediates its biological effects through its receptor, WSX-1/T cell cytokine receptor (TCCR), which is homologous to the IL-12Rβ2 subunit. Protein gp130 serves as a functional signal-transducing molecule for IL-27. |
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| Immunogen | Mouse IL-27-OVA |
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| Other Names | Interleukin-27 p28, IL-27-A, IL-27 subunit alp |
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| Gene, Accession # | Gene ID: 246779 |
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| Catalog # | 516906 |
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| Price | |
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| Order / More Info | IL-27 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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