| 产品详情 |
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| Antigenic Specificity | PLZF |
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| Clone | 9E12 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | PE-Cy7 conjugate |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE/Cy7 anti-mouse PLZF. PLZF (promyelocytic leukemia zinc finger), also known as Zbtb16, Zinc finger and BTB domain-containing protein 16, Zfp145, is a member of the BTB-POZ family of transcription factors. It was first identified in a patient with acute promyelocytic leukemia, where a reciprocal chromosomal translocation t(11;17)(q23;q21) resulted in a fusion with RARA gene encoding retinoic acid receptor alpha. Expression of this transcriptional repressor in immune cells differs between human and mouse. In humans, PLZF is expressed in CD34+ progenitor cells and in primitive multipotent hematopoietic cell lines, NK cells, γ/δ T cells, CD4+ and CD8+ T cells. It is also expressed in MR1-specific mucosal-associated invariant T cells as well as in MHC class II-restricted T cells that develop via a thymocyte-thymocyte interaction. PLZF is involved in NK cell function, cellular quiescence, and growth suppression. It also inhibits gene expression induced by retinoic acid receptor. In mice, PLZF is highly expressed in immature CD1d-resricted invariant NKT (iNKT) cells, a subset of γ/δ (Vg1.1+Vd6.3+) T cells, and non-invariant CD1d-restricted T cells. PLZF exists as a homodimer or in complex with PLZP, and has been shown to be involved in the development of NKT cells. It is also reported to be expressed in embryonic tissues, giving rise to hematopoietic progenitors. |
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| Immunogen | Combination of peptides covering the amino, carboxyl and hinge regions of the PLZF. |
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| Other Names | Promyelocytic leukemia zinc finger, Zbtb16, Zinc finger and BTB domain-containing protein 16, Zfp145 |
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| Gene, Accession # | Gene ID: 235320 |
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| Catalog # | 145805 |
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| Price | |
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| Order / More Info | PLZF Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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