| 产品详情 |
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| Antigenic Specificity | PIR-A/B |
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| Clone | 6C1 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG1, κ |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE anti-mouse PIR-A/B. Paired-immunoglobulin-like receptor (PIR) is a type I transmembrane protein, containing six Ig-like domains. Two isoforms (PIR-A and PIR-B) have been reported for this molecule. PIR-A/B is expressed on B cells, mast cells, macrophages, granulocytes, eosinophils, and dendritic cells. PIR-A requires association with FcRγc for its cell surface expression and to act as an activating receptor. The ligand for PIR-A is MHC class I. PIR-B is an inhibitory receptor with 3 ITIM motifs on its cytoplasmic tail; when phosphorylated, they recruit the tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. MHC class I, Nogo, MAG, and OMgp are the ligands for PIR-B. |
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| Immunogen | Recombinant extracellular domains 1 and 2 of PIR-A |
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| Other Names | PIRA1, PIR-B Leukocyte immunoglobulin-like receptor 3, LIR-3, GP91 |
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| Gene, Accession # | Gene ID: 18722, 18733 |
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| Catalog # | 144103 |
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| Price | |
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| Order / More Info | PIR-A/B Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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