| 产品详情 |
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| Antigenic Specificity | PIK3R1 |
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| Clone | W16101A |
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| Host Species | Rat |
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| Reactive Species | human, mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-PIK3R1. Phosphatidylinositol 3-kinase (PI3K) is a heterodimer comprised of a catalytic subunit encoded by PIK3CA (p110α) and one of a number of regulatory subunits. PIK3R1, also known as PI3K p85-alpha, is an 85kD regulatory subunit of PI3K. Upon activation of the receptor tyrosine kinases, PI3K phosphorylates inositol lipids to phosphatidylinositol-3,4,5-trisphosphate (PIP3), subsequently leads to activation of AKT and downstream effectors. The PI3K signaling regulates various cellular processes such as protein synthesis, cell growth, cell cycle progression, cell proliferation, angiogenesis, and survival. In addition, PI3K pathway has been found to play important roles in tumorigenesis and cancer progression. PIK3R1 appears to be a tumor suppressor due to its ability to stabilize the catalytic subunit of PI3K. Mutations in PIK3R1 have been associated with the autosomal dominant disorder SHORT syndrome. |
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| Immunogen | Human PIK3R1 recombinant protein (1-250 a.a.) expressed in E. coli. |
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| Other Names | Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, GRB1, |
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| Gene, Accession # | Gene ID: 5295 |
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| Catalog # | 697102 |
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| Price | |
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| Order / More Info | PIK3R1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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