| 产品详情 |
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| Antigenic Specificity | VEGFR-3 |
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| Clone | AFL4 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | IHC, ELISA, IP, Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-mouse VEGFR-3 (FLT-4). VEGFR-3, also known as FLT4, is a member of the Tyr protein kinase family. The extracellular portion of VEGFR-3 contains 7 immunoglobulin (Ig)-like domains and the cytoplasmic portion contains a protein kinase domain. FLT4 regulates angiogenesis and lymphangiogenesis, its ligands are VEGF-C and D and its binding is mediated by the 2nd and 3rd Ig-like domains of FLT4. During fetal development VEGFR-3 is expressed on endothelial cells, however, in the adult mice, the vascular endothelial cells lose VEGFR-3 expression, but the lymphatic endothelium expresses it constitutively. In addition, VEGFR-3 expression can be induced in tumors with active angiogenesis. |
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| Immunogen | VEGFR-3-Fc fusion protein |
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| Other Names | Vascular endothelial growth factor receptor 3, FLT-4, Fms-like tyrosine kinase 4 |
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| Gene, Accession # | Gene ID: 14257 |
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| Catalog # | 140902 |
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| Price | |
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| Order / More Info | VEGFR-3 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 23031500,23150542 |
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