| 产品详情 |
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| Antigenic Specificity | Fibrillarin |
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| Clone | 38F3 |
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| Host Species | Mouse |
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| Reactive Species | human, rat, Drosophila, S. pombe, C. elegans,, plants |
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| Isotype | IgG1 |
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| Format | unconjugated |
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| Size | 200 µl |
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| Concentration | n/a |
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| Applications | Western Blot (WB), ICC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Anti-Fibrillarin. Nop1p was originally identified as a nucleolar protein of bakers yeast, S. cerevisiae (accession P15646). The Nop1p protein is 327 amino acids in size (34.5kD), is essential for yeast viability, and is localized in the nucleoli. It is now known to be part of the small subunit processome complex, involved in the processing of pre-18S ribosomal RNA. Nop1p is the yeast homologue of a protein apparently found in all eukaryotes and archea generally called fibrillarin. Fibrillarin/Nop1p is extraordinarily conserved, so that the yeast and human proteins are 67% identical, and the human protein can functionally replace the yeast protein. This means that suitably cross-reactive antibodies to Nop1p/fibrillarin, like MCA-38F3, can be used to reveal nucleoli and study fibrillarin/Nop1p in all eukaryotes and archea tested to date. |
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| Immunogen | 38F3 was raised against yeast nuclear preparations. |
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| Other Names | RRNA 2'-O-methyltransferase fibrillarin, 34 kDa nucleolar scleroderma antigen, RNA, U3 small nucleolar interacting protein 1, MMS-581S-200 |
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| Gene, Accession # | Gene ID: 2091 |
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| Catalog # | 905001 |
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| Price | |
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| Order / More Info | Fibrillarin Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21331097,22383580,22869524 |
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