| 产品详情 |
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| Antigenic Specificity | IKBKB |
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| Clone | W15160A |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), KO/KD-Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-IKBKB (IKKβ). NF-kappa-B (NF-κB) signaling pathway is involved in many biological responses such as immune response, growth control, DNA damage and other cellular stresses. This pathway is regulated by the inhibitory IKK proteins (composed by IKKα, IKBKB/IKKβ and IKKγ) which complex with NF-κB/Rel transcription factors in the cytosol. As part of the IKK complex, IKBKB phosphorylates inhibitors of NF-κB on 2 serine residues. These phosphorylations cause polyubiquitination and subsequent degradation of the NF-κB inhibitors. In turn, free NK-κB translocates into nucleus and activates the downstream gene transcription. Upon cytokine stimulation, phosphorylation of Ser-177 and -181 enhances IKBKB activity; on the other hand, acetylation of Thr-180 residue prevents IKKβ phosphorylation and activation, thus blocking the inhibition of NF-κB pathway. |
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| Immunogen | Partial human IKBKB recombinant protein (520-745 a.a.) expressed in E. coli. |
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| Other Names | Inhibitor of nuclear factor kappa-B kinase subunit beta, IKKβ, IKKbeta, NFKBIKB, IKKB, IKK2 |
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| Gene, Accession # | Gene ID: 3551 |
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| Catalog # | 688402 |
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| Price | |
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| Order / More Info | IKBKB Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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| 产品资料 |
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