| 产品详情 |
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| Antigenic Specificity | CD126 (IL-6 R a chain) |
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| Clone | D7715A7 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, κ |
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| Format | purified, azide-free |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), Block, IP, Neut |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LEAF™ Purified anti-mouse CD126 (IL-6Ra chain). CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on activated T and B cells, monocytes, hepatocytes, and plasma cells. High affinity IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity, but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself, but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. The D7715A7 (15A7) antibody blocks IL-6/IL-6 receptor interactions. |
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| Immunogen | OKT4 hybridoma cells |
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| Other Names | IL-6 Receptor α chain, IL-6R |
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| Gene, Accession # | Gene ID: 16194 |
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| Catalog # | 115807 |
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| Price | |
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| Order / More Info | CD126 (IL-6 R a chain) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18156493,18292497,20628063 |
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