| 产品详情 |
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| Antigenic Specificity | CD115 |
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| Clone | 9-4D2-1E4 |
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| Host Species | Rat |
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| Reactive Species | human, African green, baboon, cynomolgus, rhesus |
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| Isotype | IgG1, κ |
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| Format | Brilliant Violet 421™ conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Brilliant Violet 421™ anti-human CD115 (CSF-1R). CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitinylation of intracellular residues. The natural ligands of CD115 include M-CSF and IL-34. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, plasmacytoid and conventional dendritic cells, and osteoclasts. |
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| Immunogen | C-fms transduced Kirsten strain murine sarcoma virus transformed NRK cells. |
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| Other Names | M-CSFR,CSF-1R, FMS, CSF-1 Receptor |
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| Gene, Accession # | Gene ID: 1436 |
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| Catalog # | 347321 |
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| Price | |
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| Order / More Info | CD115 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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