| 产品详情 |
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| Antigenic Specificity | CD115 |
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| Clone | AFS98 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | Alexa Fluor® 647 conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor® 647 anti-mouse CD115 (CSF-1R). CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts. |
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| Immunogen | n/a |
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| Other Names | CSF-1R, M-CSFR, c-fms |
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| Gene, Accession # | Gene ID: 12978 |
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| Catalog # | 135530 |
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| Price | |
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| Order / More Info | CD115 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 22393124 |
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| 产品资料 |
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