| 产品详情 |
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| Antigenic Specificity | Caspase-2L |
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| Clone | W16017A |
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| Host Species | Rat |
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| Reactive Species | human, mouse |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Caspase-2L. Caspase-2 is an evolutionarily conserved member of the caspase family. Caspases are cycteine-rich proteases, known to be activated in response to apoptotic stimuli including DNA damage, ER stress, oxidative stress, and heat shock. Activated caspases hydrolyze structural proteins in the cells that in turn results in apoptosis. Upon activation, Caspase-2 leads to proteolytic cleavage of the pro-apoptotic protein Bid and facilitates permeabilization of mitochondrial outer membrane. In addition to its function in cell death, Caspase-2 has been shown to participate in affecting genomic stability, aging, autophagy, and tumor suppression. Reduced Caspase-2 expression has been found to associate with Burkitt's lymphoma and correlate with poor prognosis in myeloid leukemia. |
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| Immunogen | Partial human caspase-2 recombinant protein (203-452 a.a.) expressed in E. coli. |
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| Other Names | CASP-2, Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2), Protease ICH-1, |
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| Gene, Accession # | Gene ID: 835 |
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| Catalog # | 697002 |
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| Price | |
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| Order / More Info | Caspase-2L Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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