| 产品详情 |
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| Antigenic Specificity | Bcl-2 |
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| Clone | BCL/10C4 |
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| Host Species | Mouse |
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| Reactive Species | mouse, rat |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB), IP, Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-Bcl-2. Bcl-2 (B-cell leukemia 2) is an apoptotic protein and a member of the Bcl-2 family containing BH1-4 domains. Two reported isoforms exist α=25 kD; β=22 kD. The Bcl-2 protein forms homo- or hetero-dimers with other Bcl-2 family members. Bcl-2 is distributed in the outer mitochondrial membrane, the nuclear envelope, and the endoplasmic reticulum. This protein blocks apoptotic death by controlling mitochondrial membrane permeability. Cleavage of Bcl-2 can convert to pro-apoptotic (by cleavage of BH4 domain). Bcl-2 has been reported to regulate cell cycle progression via ROS. This protein is modified by ASK1/JNK1, PKC, ERKs, and stress-activated kinase phosphorylation and can be ubiquitinated. Bcl-2 has been shown to interact with Apaf-1, Raf-1, TP53BP2, caspase-3, and form heterodimers with Bax, Bad, Bak, Bcl-xL, and Bag-1. Clone BCL/10C4 has been shown to be useful for Western blotting, immunoprecipitation, and immunofluorescence of the mouse and rat Bcl-2 protein. |
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| Immunogen | N-terminal, Amino acid residues 61-76 of mouse Bcl-2 |
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| Other Names | B-cell leukemia 2 |
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| Gene, Accession # | Gene ID: 596 |
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| Catalog # | 633501 |
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| Price | |
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| Order / More Info | Bcl-2 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 21828272,22828507 |
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