| 产品详情 |
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| Antigenic Specificity | Granzyme C |
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| Clone | SFC1D8 |
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| Host Species | Armenian Hamster |
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| Reactive Species | mouse |
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| Isotype | IgG |
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| Format | fluorescein (FITC) conjugate |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | FITC anti-mouse Granzyme C. Granzyme C is a serine protease that is found in the granules of cytotoxic T lymphocytes and natural killer cells (NKs). It induces the apoptosis of target cells by the externalization of phosphatidylserine, nuclear condensation and collapse, as well as the introduction of single-stranded DNA nicks. It can also induce apoptosis via mitochondrial swelling, which results in the loss of membrane potential. Reported studies show that granzyme C can support CTL-mediated killing in the absence of granzyme A or B. Additionally, wild-type mice have delayed upregulation of granzyme C relative to granzyme B and a mutation in the granzyme B gene shows earlier upregulation of granzyme C. Further studies show that in the event that granzyme B fails, the mouse models infected with persistent viruses have delayed expression of protection provided by granzyme C. |
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| Immunogen | Purified recombinant granzyme C in CFA and boosted in IFA. |
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| Other Names | CCP2, Ctla5, Ctla-5, AI323531, B10, GzmC |
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| Gene, Accession # | Gene ID: 14940 |
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| Catalog # | 150806 |
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| Price | |
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| Order / More Info | Granzyme C Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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