| 产品详情 |
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| Antigenic Specificity | eIF-2A |
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| Clone | P83A7A8 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-eIF-2A. eIF-2A was initially considered to be a eukaryotic functional counterpart of the prokaryotic translation initiation factor IF2, because it binds methionyl-tRNAi to 40 S subunits in a codon-dependent manner. But recent studies proved that eIF2-mediated pathway is far more efficient, and only eIF2 is able to form the 80S initiation complex on native globin mRNA. eIF2 is responsible for the loading of Met-tRNAi onto the ribosome in the majority of translation initiation events in eukaryotes, while eIF-2A is involved in the translation of a limited subset of mRNAs.Homologues of eIF-2A are found in a wide range of eukaryotic species, indicating that eIF-2A plays some conserved roles. eIF-2A was reported to be involved in antigen presentation by major histocompatibility complex (MHC) class I molecules. Some antigenic precursors are translated from CUG codons via an unknown mechanism, which is different from the conventional methionine-initiated mechanism. Ribosome profiling experiments also revealed that translation initiation at CUG or GUG codons is a common event in yeast and human, and is not limited to antigen presentation by MHC class I molecules. Under stress conditions, such as amino acid starvation, heat shock and viral infection, eIF-2A migrates from the nucleus to the cytoplasm, where it is utilized for the translation of alphavirus 26S mRNA and hepatitis C viral (HCV) mRNA. So eIF-2A is considered to be a tRNA-loading factor in unconventional translation initiation events, such as non-AUG translation initiation, and an alternative factor of eIF2 when the active eIF2 is limited. |
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| Immunogen | Purified recombinant fragment of human eIF-2A (448-576 a.a.) expressed in E. coli. |
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| Other Names | Eukaryotic translation initiation factor 2A, 65 kD eukaryotic translation initiation factor 2A |
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| Gene, Accession # | Gene ID: 83939 |
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| Catalog # | 690302 |
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| Price | |
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| Order / More Info | eIF-2A Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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