| 产品详情 |
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| Antigenic Specificity | TSC2 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | peptide affinity purified |
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| Size | 80 µl, 400 µl |
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| Concentration | n/a |
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| Applications | WB. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1364-1393 amino acids from the Central region of human TSC2. |
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| Immunogen | n/a |
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| Other Names | TSC2; LAM; Tuberous sclerosis 2 protein; Tuberous sclerosis 2; TSC4; Tuberin |
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| Gene, Accession # | SwissProt: P49815 |
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| Catalog # | abx034676 |
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| Price | |
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| Order / More Info | TSC2 Antibody from ABBEXA |
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| Product Specific References | n/a |
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| 产品资料 |
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