| 产品详情 |
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| Antigenic Specificity | BRCA1 |
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| Clone | monoclonal |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 100 µg |
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| Concentration | 1.0 mg/ml |
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| Applications | ELISA, WB, IHC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor.The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC).This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes.This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination.Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers.Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described.A related pseudogene, which is also located on chromosome 17, has been identified. |
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| Immunogen | Purified recombinant fragment of human BRCA1 (AA: 229-335) expressed in E. coli. |
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| Other Names | aeBRCA1; Breast cancer type 1 susceptibility protein; BRCA1; BRCAI; BRCC1; BROVCA1; IRIS; PSCP; RNF53; familial breast/ovarian cancer gene 1; PNCA4; PPP1R53; Ring Finger Protein 53 |
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| Gene, Accession # | BRCA1, Gene ID: 672, SwissProt: P38398 |
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| Catalog # | abx015781 |
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| Price | |
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| Order / More Info | BRCA1 Antibody from ABBEXA |
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| Product Specific References | n/a |
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