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| Antigenic Specificity | LIMK1 (pT508) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µl, 100 µl, 200 µl |
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| Concentration | > 1 mg/ml |
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| Applications | WB, IHC, IF/ICC. RUO |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | LIMK1 (pT508) Antibody is a Rabbit Polyclonal antibody against LIMK1 (pT508). There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
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| Immunogen | Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding T508 of human LIMK1. |
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| Other Names | kinase LIMK1; KIZ-1; LIM domain kinase 1; LIMK; LIMK-1; LIMK1 |
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| Gene, Accession # | LIMK1, Gene ID: 3984, SwissProt: P53667 |
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| Catalog # | abx000434 |
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| Price | |
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| Order / More Info | LIMK1 (pT508) Antibody from ABBEXA |
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| Product Specific References | n/a |
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