| Amine-to-amine crosslinkers with polyethylene glycol (PEG) spacer arms. BS(PEG)5 and BS(PEG)9 are bis-succinimide ester-activated PEG compounds for crosslinking between primary amines (–NH2) in proteins and other molecules. The N-hydroxysuccinimide ester (NHS) groups at either end of the PEG5 or PEG9 spacer react specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. 
Highlights:- Irreversibly crosslink proteins or peptides by flexible PEG spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages including increased stability reduced tendency toward aggregation and reduced immunogenicity
- Ideal for small molecule or peptide conjugations
- NHS esters react with –NH2 groups at pH 7-9 forming stable amide bonds
- Reactive goups: NHS esters (homobifunctional)
- Reactive toward: primary amines
| Alternative Names for BS(PEG)n:- Bis-NHS-dPEG
- NHS-PEG-NHS
- BS(PEO)5
- Bis(NHS)PEO5
- BS-PEO9
- dPEG NHS ester
- Bis-succinimide ester PEG 400
|
Related ProductsNon-PEG Bis-NHS rosslinkers
Sulfhydryl-reactive PEG Crosslinkers
Other kinds of PEGylation Reagents Reference- Hermanson G.T. (2008). Bioconjugate Techniques Academic Press (Product # 20036)
Crosslinking reagents are available in bulk quantities with special pricing for manufacturing applications. | 
