This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases.This kinase contains 2 non-identical kinase catalytic domains and phosphorylates several residues of the S6 ribosomal protein.The kinase activity of this protein leads to an increase in protein synthesis and cell proliferation.Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some breast cancer cell lines.Alternate translational start sites have been described and alternate transcriptional splice variants have been observed but have not been thoroughly characterized.
| Target |
RPS6KB1 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, FCM |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human RPS6KB1 expressed in E. coli. |
| Purification |
Purified antibody |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
59 kDa |
| Swiss Prot |
P23443
|
| GeneID |
6198
|
| Gene Symbol |
RPS6KB1 |
| OMIM |
608938
|
| HGNC |
10436 |
| Ensembl |
ENSG00000108443 |
| Concentration |
1.0 mg/ml |
| Buffer |
PBS with 0.05% sodium azide and 0.5% protein stabilizer. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |