This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins.This protein binds directly to the F-box motif found in F-box proteins.SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome.Specific F-box proteins recognize different target protein (s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development.Studies have also characterized the protein as an RNA polymerase II elongation factor.Alternative splicing of this gene results in two transcript variants.A related pseudogene has been identified on chromosome 7.
| Target |
SKP1 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, FCM |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human SKP1 expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
19 kDa |
| Swiss Prot |
P63208
|
| GeneID |
6500
|
| Gene Symbol |
SKP1 |
| OMIM |
601434
|
| HGNC |
10899 |
| Ensembl |
ENSG00000113558 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |