Phospho-SEK1/MKK4 (Thr261) Antibody detects endogenous levels of SEK1/MKK4 only when phosphorylated at Threonine 261. MKK4 dual specificity kinase of the STE7 family that phosphorylates and activates JNK1 and -2 as well as p38 but not ERK1 or -2. Mediates cellular responses to various cellular stresses and inflammatory cytokines. Phosphorylation by Akt inhibits MKK4 and suppresses stress-activated signal transduction.
| Target |
SEK1/MKK4 (pT261) |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P45985
|
| GeneID |
6416
|
| Gene Symbol |
MAP2K4 |
| OMIM |
601335
|
| Enzyme Commission Number |
EC 2.7.12.2 |
| HGNC |
6844 |
| Ensembl |
ENSG00000065559 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |