SGK1 Antibody is a Rabbit Polyclonal antibody against SGK1. Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to AktSGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoidsSGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathwaysInduction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulationSGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretionSGK is negatively regulated by ubiquitination and proteasome degradationThe MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78.
| Target |
SGK1 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human SGK1. |
| Purification |
Affinity Chromatography. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
O00141
|
| GeneID |
6446
|
| Gene Symbol |
SGK1 |
| Buffer |
PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |