产品名称 SHC1 (pY349) Antibody
产品货号 Catalogue No: abx000316
产品价格 现货询价,电话:010-67529703
产品规格 Available Options * Size: 50 µl 100 µl 200 µl
产品品牌 abbexa
产品概述
产品详情
SHC1 (pY349) Antibody is a Rabbit Polyclonal antibody against SHC1 (pY349). This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Target SHC1 (pY349)
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IF/ICC
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding Y349 of human SHC1.
Purification Affinity purified.
Form Liquid
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight Calculated MW: 40 kDa/46 kDa/51 kDa/62 kDa
Observed MW: 50 kDa
Swiss Prot P29353
GeneID 6464
Gene Symbol SHC1
Concentration > 1 mg/ml
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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