产品名称 Signal Transducer And Activator of Transcription 1 (STAT1) Antibody
产品货号 Catalogue No: abx034925
产品价格 现货询价,电话:010-67529703
产品规格 Available Options * Size: 80 µl 400 µl
产品品牌 abbexa
产品概述
产品详情
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Target STAT1
Reactivity Human
Host Mouse
Clonality Monoclonal
Tested Applications WB
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Immunogen Purified His-tagged Human STAT1 protein
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Isotype IgG1
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Swiss Prot P42224
NCBI Accession NP_009330.1 NP_644671.1
Buffer PBS containing 0.09% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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