产品名称 Signal Transducer And Activator of Transcription 5B (STAT5B) Antibody
产品货号 Catalogue No: abx011810
产品价格 现货询价,电话:010-67529703
产品规格 Available Options * Size: 100 µl
产品品牌 abbexa
产品概述
产品详情
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Target STAT5B
Reactivity Human
Host Mouse
Clonality Monoclonal
Tested Applications ELISA, WB
Recommended dilutions ELISA: 1/10000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Immunogen Purified recombinant fragment of human STAT5B expressed in E. Coli.
Purification Unpurified Ascites.
Isotype IgG1
Conjugation Unconjugated
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Molecular Weight 90 kDa
Swiss Prot P51692
GeneID 6777
Gene Symbol STAT5B
OMIM 604260
HGNC 11367
Ensembl ENSG00000173757
Buffer Ascitic fluid containing 0.03% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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