产品名称 Signal Transducer And Activator of Transcription 5B (STAT5b) Antibody
产品货号 Catalogue No: abx028493
产品价格 现货询价,电话:010-67529703
产品规格 Available Options * Size: 80 µl 400 µl
产品品牌 abbexa
产品概述
产品详情
STAT5b is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
Target STAT5b
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Tested Applications WB, IHC
Recommended dilutions Optimal dilutions/concentrations should be determined by the end user.
Immunogen KLH-conjugated synthetic peptide between 760-787 amino acids from the C-terminal region of human STAT5b.
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Isotype IgG
Conjugation Unconjugated
Storage Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Swiss Prot P51692
NCBI Accession NP_036580.2
Buffer PBS containing 0.09% sodium azide.
UNSPSC Code 12352203
Availability Shipped within 5-10 working days.
Note This product is for research use only.
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