PRODUCT NUMBER:

Synonym: AGP, Orosomucoid

MW: ~45,000 Da under Reducing and Non-Reducing Conditions by SDS-PAGE
Extinction Coefficient: 0.89 (0.1% solution, 1 cm path length)

Salt-free lyophilized solid

Storage: -20°C

Alpha 1 Acid Glycoprotein A1AGP, AGP, OMD purified from Human plasma. Buy direct from the manufacturer.

Found in human plasma in concentrations of 55-140 mg per 100 ml. Classical standard glycoprotein for studies on the structure of the oligosaccharide units. Carbohydrate content is 40%. Its biological significance is unknown although it can bind progesterone 15 times as strongly as albumin. Sialic-acid-deficient alpha-1-AG has an affinity for vitamin B-12. Clinically, alpha 1 acid glycoprotein is an acute-phase reactant that together with haptoglobin is an indicator of acute inflammation. The alpha 1 acid glycoprotein:haptoglobin ratio is useful in studies of bone marrow disorders, hemolytic processes and metastases.

Ref: Schmid, K. et al. 1973. Biochemistry. 12, 2711; Putnam, F.W. 1984. The Plasma Proteins. (Putnam, F.W., ed.) 2nd Ed. Vol. IV, 5.

Purity: >=95% by SDS-PAGE

Prepared from plasma shown to be non reactive for HBsAg, anti-HBc, and negative for anti-HIV 1 & 2 by current FDA testing standards.

Athens Research & Technology products are laboratory reagents and are not to be administered to humans or used for any drug purpose.
For research use or for use in further manufacturing.

Product Citations:
Brown, L. J., et al. "Miniaturized ultra high field asymmetric waveform ion mobility spectrometry combined with mass spectrometry for peptide analysis." Analytical chemistry 82.23 (2010): 9827-9834.

Ramadass M, Ghebrehiwet B, Smith RJ, Kew RR.
Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes during Complement Activation: Possible Implications in C3 Glomerulopathies.
J Immunol. 2014 Feb 1;192(3):1220-30. doi: 10.4049/jimmunol.1302288. Epub 2013 Dec 23.