产品名称

JSH 23 | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | Axon 2349 | Axon Ligand™ with >99% purity available from stock from supplier Axon Medchem

产品货号

Axon 2349 CAS [749886-87-1] MF C16H20N2MW 240.34 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells. JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM). KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

JSH 23

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2349

CAS [749886-87-1]

MF C16H20N2
MW 240.34

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

JSH 23

Description

Inhibitor of NF-κB transcription and nuclear translocation of p65 (IC50 value 7.1 µM for inhibition of LPS-induced NF-κB transcriptional activity) without affecting IκBα degradation, which is a very rare mode of action. JSH 23 inhibited not only LPS-induced expressions of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS-induced apoptosis of the RAW 264.7 cells.
JSF 23 also inhibits NO production in LPS-stimulated macrophages RAW 264.7 (IC50 value 14.4 µM).

KEYWORDS: JSH 23 | supplier | NF-κB inhibitor | JSH23 | CAS [749886-87-1] | NF-κB | Inhibitor | p65 | IκB | inflammation | transcription factor | Pro-inflammatory | cytokine | LPS | IKK | RAW 264.7 | COX-2