产品名称

ML334 | NRF2 acitivator | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | Axon 2641 | Axon Ligand™ with >99% purity available from stock from supplier Axon Medchem

产品货号

Axon 2641 CAS [1432500-66-7] MF C26H26N2O5MW 446.50 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Activator of NRF2 signaling by inhibition of Keap1-NRF2 protein-protein interaction (PPI; IC50 value 1.6 - 2.3 µM in a fluorescence polarisation assay using Keap1 Kelch domain/NRF2-ETGE peptide; Kd value 1 μM to Keap1 Kelch domain). ML 334 stimulates NRF2 expression and nuclear translocation, and induces antioxidant response elements (ARE) and transcription of HO-1 and TRX1 proteins. KEYWORDS: ML 334 | supplier | NRF2 acitivator | LH 601A | ML334 | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | DNA-RNA | NRF | Keap | Transcription Factor | Keap1-NRF2 | protein-protein interaction | Neurodegenerative | PPI | Kelch domain | expression | translocation | antioxidant response elements | HO-1 | TRX1

产品价格

现货询价，电话：010-67529703

产品规格

产品品牌

axonmedchem

产品概述

产品详情

ML334 - LH601A

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2641

CAS [1432500-66-7]

MF C26H26N2O5
MW 446.50

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

ML334

Description

Activator of NRF2 signaling by inhibition of Keap1-NRF2 protein-protein interaction (PPI; IC50 value 1.6 - 2.3 µM in a fluorescence polarisation assay using Keap1 Kelch domain/NRF2-ETGE peptide; Kd value 1 μM to Keap1 Kelch domain). ML 334 stimulates NRF2 expression and nuclear translocation, and induces antioxidant response elements (ARE) and transcription of HO-1 and TRX1 proteins.

KEYWORDS: ML 334 | supplier | NRF2 acitivator | LH 601A | ML334 | LH601A | ML-334 | LH-601A | CAS [1432500-66-7] | DNA-RNA | NRF | Keap | Transcription Factor | Keap1-NRF2 | protein-protein interaction | Neurodegenerative | PPI | Kelch domain | expression | translocation | antioxidant response elements | HO-1 | TRX1

L Hu et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43.

X Wen et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6.

E Jnoff et al. Binding mode and structure-activity relationships around direct inhibitors of the Nrf2-Keap1 complex. ChemMedChem. 2014 Apr;9(4):699-705.

Angiogenesis Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Immunology Pain & Inflammation Transcription Factors NF-κB JAK-STAT NRF TF class 1.1.1.2.3

Activator of NRF2 by inhibition of Keap1-NRF2 interactions

Chemical name

(1S,2R)-2-((S)-1-((1,3-dioxoisoindolin-2-yl)methyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)cyclohexanecarboxylic acid

Parent CAS No.

[1432500-66-7]

产品资料