Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体
英文名称: Anti-Ninjurin 2 antibody
型号:null    抗体货号: HZ-11106R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体

产品编号HZ-11106R
英文名称Ninjurin 2
中文名称神经损伤诱导蛋白2/NINJ2抗体
别 名Nerve injury induced protein 2; Ninjurin2; Ninjurin-2; NINJ2; NINJ2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 细胞粘附分子 细胞膜蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog,
Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量16kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Ninjurin 2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体PubMedPubMed
产品介绍background:
Ninjurin family proteins are multi-pass membrane proteins induced by nerve injury in Schwann cells and dorsal root ganglion neurons. Nunjurin proteins act as homophilic cell adhesion molecules that promote axonal growth. Ninjurin proteins also play a role in the formation and function of other tissues. Ninjurin-1 is widely expressed in adult and embryonic tissues, particularly those with epithelial origin. Ninjurin-2 is also widely expressed, with highest levels in adult bone marrow and peripheral blood lymphocytes and embryo liver, thymus and heart. The genes that encode the Ninjurin proteins map to a region known to cause several genetic disorders, including hereditary sensory neuropathy type I and type II (HSN1 and HSN2). However, no link between mutations in the genes encoding Ninjurins and the diseases have been found.

Function:
Ninjurin2 is an homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

Subunit:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues.

Subcellular Location:
Membrane; Multi-pass membrane protein

Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体Tissue Specificity:
Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney.

Similarity:
Belongs to the ninjurin family.

Database links:
Entrez Gene: 4815 Human
GenBank: BC057766 Human
Omim: 607297 Human
SwissProt: Q9NZG7 Human
Unigene: 656450 Human

Ninjurin 2,神经损伤诱导蛋白2/NINJ2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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Leptin receptor,瘦素受体抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Leptin是一种分子量为16kDa的脂肪组织源***,由脂肪细胞分泌的,具有强亲水性,以单体形式存在于血浆中。 Leptin 具有广泛的生物学效应,作用于下丘脑,调节食欲、能量代谢及体重。Leptin 还可能作为脂肪-胰岛内分泌轴一部分,参与胰岛素分泌的调节。Leptin receptor (OB-R)是与gp130最密切相关的信号转导的共同成分,属1类细胞因子超家族,下丘脑有丰富的Leptin receptor,在其它部位也有分布,但水平较低,如:胰岛素B细胞、脉络丛、肝、肺、心、肾、睾丸、淋巴细胞和脂肪细胞中。人类存在四个异性体,均为单跨膜受体。其中OB-Rb在胞内结构域最长,是唯一能进行信号传导并调节热量摄入和能量消耗的异性体,分子量为132kDa。