MARCH2,膜相关环指蛋白2抗体

产品编号HZ-9336R
英文名称MARCH2
中文名称膜相关环指蛋白2抗体
别 名E3 ubiquitin protein ligase MARCH2; E3 ubiquitin-protein ligase MARCH2; EC 6.3.2.- antibody HSPC240; MARCH II; MARCH-II; march2; MARH2_HUMAN antibody Membrane associated RING CH protein II; Membrane associated ring finger (C3HC4) 2; Membrane associated RING finger protein 2; Membrane-associated RING finger protein 2; Membrane-associated RING-CH protein II; RING finger protein 172; RNF172.
说 明 书0.1ml 0.2ml
研究领域细胞生物 通道蛋白 锌指蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
MARCH2,膜相关环指蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量27kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MARCH2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MARCH2,膜相关环指蛋白2抗体PubMedPubMed
产品介绍background:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.

Function:
E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6.

Subunit:
Interacts with STX6 (By similarity). Interacts with MARCH3.

Subcellular Location:
Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane.

Tissue Specificity:
Broadly expressed.

MARCH2,膜相关环指蛋白2抗体Similarity:
Contains 1 RING-CH-type zinc finger.

Gene ID:
51257

Database links:
Entrez Gene: 51257 Human
Entrez Gene: 224703 Mouse
Entrez Gene: 362849 Rat
Omim: 613332 Human
SwissProt: Q9P0N8 Human
SwissProt: Q99M02 Mouse
SwissProt: Q5I0I2 Rat
Unigene: 631861 Human
Unigene: 374865 Mouse
Unigene: 145219 Rat

MARCH2,膜相关环指蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.